Chemotherapy for gynecologic malignancies.

TitleChemotherapy for gynecologic malignancies.
Publication TypeJournal Article
Year of Publication1995
AuthorsVermorken, JB, Hoekman, K
JournalCurr Opin Oncol
Volume7
Issue5
Pagination457-65
Date Published1995 Sep
ISSN1040-8746
KeywordsAntineoplastic Agents, Antineoplastic Combined Chemotherapy Protocols, Carcinosarcoma, Drug Resistance, Neoplasm, Endometrial Neoplasms, Female, Genital Neoplasms, Female, Humans, Ovarian Neoplasms, Pregnancy, Salvage Therapy, Trophoblastic Neoplasms, Uterine Cervical Neoplasms
Abstract

Platinum-based chemotherapy is still the cornerstone in the chemotherapeutic approach of ovarian cancer patients. Recent advances include the introduction of paclitaxel in first-line chemotherapy and the demonstrated importance of administering cisplatin intraperitoneally in patients with small-volume disease. DNA repair and apoptosis are increasingly recognized as important processes involved in resistance to chemotherapy. Tamoxifen use is associated with a higher risk of endometrial cancer, with duration and cumulative dose of tamoxifen as additional factors. Hormonal therapy continues to be an important component of treatment of patients with advanced or recurrent endometrial cancer. Combination chemotherapy induces higher response rates in such patients. However, any advantage towards an improved survival remains a controversial issue. Isotretinoin plus interferon alfa-2a for squamous cell carcinoma of the cervix is still a topic of interest. There is a great need for agents and interventions with more efficacy and more specificity for the biology of the different gynecologic malignancies.

Alternate JournalCurr Opin Oncol
PubMed ID8541392