Gynecological Cancers Translational, Research Implementation, and Harmonization: Gynecologic Cancer InterGroup Consensus and Still Open Questions.

TitleGynecological Cancers Translational, Research Implementation, and Harmonization: Gynecologic Cancer InterGroup Consensus and Still Open Questions.
Publication TypeJournal Article
Year of Publication2019
AuthorsBagnoli, M, Shi, TYan, Gourley, C, Speiser, P, Reuss, A, Nijman, HW, Creutzberg, CL, Scholl, S, Negrouk, A, Brady, MF, Hasegawa, K, Oda, K, McNeish, IA, Kohn, EC, Oza, AM, MacKay, H, Millan, D, Bennett, K, Scott, C, Mezzanzanica, D
JournalCells
Volume8
Issue3
Date Published2019 Feb 26
Type of ArticleJournal
ISSN2073-4409
Abstract

In the era of personalized medicine, the introduction of translational studies in clinical trials has substantially increased their costs, but provides the possibility of improving the productivity of trials with a better selection of recruited patients. With the overall goal of creating a roadmap to improve translational design for future gynecological cancer trials and of defining translational goals, a main discussion was held during a brainstorming day of the Gynecologic Cancer InterGroup (GCIG) Translational Research Committee and overall conclusions are here reported. A particular emphasis was dedicated to the new frontier of the immunoprofiling of gynecological cancers. The discussion pointed out that to maximize patients' benefit, translational studies should be integral to clinical trial design with standardization and optimization of procedures including a harmonization program of Standard Operating Procedures. Pathology-reviewed sample collection should be mandatory and ensured by dedicated funding. Biomarker validation and development should be made public and transparent to ensure rapid progresses with positive outcomes for patients. Guidelines/templates for patients' informed consent are needed. Importantly for the public, recognized goals are to increase the involvement of advocates and to improve the reporting of translational data in a forum accessible to patients.

DOI10.3390/cells8030200
Alternate JournalCells
PubMed ID30813545
Grant ListG0501974 / / Medical Research Council / United Kingdom
G0601891 / / Medical Research Council / United Kingdom