Independent prognostic significance of cell cycle regulator proteins p16(INK4a) and pRb in advanced-stage ovarian carcinoma including optimally debulked patients: a translational research subprotocol of a randomised study of the Arbeitsgemeinschaft Gynaek

TitleIndependent prognostic significance of cell cycle regulator proteins p16(INK4a) and pRb in advanced-stage ovarian carcinoma including optimally debulked patients: a translational research subprotocol of a randomised study of the Arbeitsgemeinschaft Gynaek
Publication TypeJournal Article
Year of Publication2007
AuthorsKommoss, S, du Bois, A, Ridder, R, Trunk, MJ, Schmidt, D, Pfisterer, J, Kommoss, F, -OVAR, AGO
JournalBr J Cancer
Volume96
Pagination306-13
KeywordsCombined Modality Therapy Cyclin-Dependent Kinase Inhibitor p16/*physiology Female Humans Ovarian Neoplasms/drug therapy/*metabolism/pathology/surgery Prognosis Prospective Studies Retinoblastoma Protein/*physiology Survival Rate
Abstract

{The purpose of the study is to test the hypothesis that expression of cell cycle regulatory proteins p16(INK4a) and pRb is significantly associated with prognosis in ovarian carcinomas. We performed immunohistochemical analysis of p16(INK4a) and pRb expression and correlated with survival in a series of 300 patients with FIGO stage IIb-IV ovarian carcinoma which were enrolled in a randomized prospective trial evaluating two different platinum and paxlitaxel chemotherapy combinations after radical surgery. p16(INK4a) negative tumours (17/300; 6%) had a significantly worse prognosis (univariate analysis, P<0.001; multivariate analysis: odds ratio 2.41