Long-term follow-up of patients with advanced ovarian carcinoma treated with chemotherapy.

TitleLong-term follow-up of patients with advanced ovarian carcinoma treated with chemotherapy.
Publication TypeJournal Article
Year of Publication1993
AuthorsThigpen, JT, Bertelsen, K, Eisenhauer, E, Hacker, NF, Lund, B, Sessa, C
JournalAnn Oncol
Volume4 Suppl 4
Date Published1993
KeywordsAntineoplastic Agents, Antineoplastic Combined Chemotherapy Protocols, Female, Follow-Up Studies, Humans, Ovarian Neoplasms, Randomized Controlled Trials as Topic, Time Factors

BACKGROUND: The evolution of the management of advanced ovarian carcinoma over the last fifteen years has resulted from a number of well-designed randomized trials involving large numbers of patients.MATERIALS AND METHODS: A critical review of long-term follow-up of patients entered onto eleven major randomized trials of advanced ovarian carcinoma has been performed.RESULTS: In the pre-platinum era no long-term survival benefit was obtained with combination compared with single agent chemotherapy. When adding cisplatin to front-line therapy at least a short-term gain in terms of superior response rate and progression-free intervals is obtained compared with non-cisplatin combination chemotherapy. Survival data are more difficult to assess due to the use of cisplatin-containing salvage therapy. Cisplatin-based combination therapy also offers enhanced patient benefit when compared with cisplatin alone. A slight advantage favouring anthracycline-containing therapy is observed, whereas no advantage is obtained with alternating cisplatin and non-cisplatin regimens or by adding BCG.CONCLUSIONS: Platinum-based combination chemotherapy is clearly associated with improved response rates and progression-free survival and, at least in some studies, better overall survival. At least six cycles of therapy should be given. Such approaches should yield long-term survival rates of 10% or better for patients with large-volume disease and 20% or better for small-volume disease.

Alternate JournalAnn. Oncol.
PubMed ID8312199