Randomised study of systematic lymphadenectomy in patients with epithelial ovarian cancer macroscopically confined to the pelvis

TitleRandomised study of systematic lymphadenectomy in patients with epithelial ovarian cancer macroscopically confined to the pelvis
Publication TypeJournal Article
Year of Publication2006
AuthorsMaggioni, A, P. Panici, B, Dell'Anna, T, Landoni, F, Lissoni, A, Pellegrino, A, Rossi, RS, Chiari, S, Campagnutta, E, Greggi, S, Angioli, R, Manci, N, Calcagno, M, Scambia, G, Fossati, R, Floriani, I, Torri, V, Grassi, R, Mangioni, C
JournalBr J Cancer
Volume95
Pagination699-704
KeywordsAdjuvant Disease Progression Female Humans *Lymph Node Excision Lymph Nodes/pathology/surgery Lymphatic Metastasis Middle Aged Neoplasm Staging Ovarian Neoplasms/drug therapy/pathology/*surgery Pelvic Neoplasms/drug therapy/pathology/*surgery Risk Factor, Adult Antineoplastic Combined Chemotherapy Protocols/therapeutic use Chemotherapy
Abstract

{No randomised trials have addressed the value of systematic aortic and pelvic lymphadenectomy (SL) in ovarian cancer macroscopically confined to the pelvis. This study was conducted to investigate the role of SL compared with lymph nodes sampling (CONTROL) in the management of early stage ovarian cancer. A total of 268 eligible patients with macroscopically intrapelvic ovarian carcinoma were randomised to SL (N=138) or CONTROL (N=130). The primary objective was to compare the proportion of patients with retroperitoneal nodal involvement between the two groups. Median operating time was longer and more patients required blood transfusions in the SL arm than the CONTROL arm (240 vs 150 min, P<0.001, and 36 vs 22%